Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

@article{Stone2007RelationshipBK,
  title={Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study},
  author={James M Stone and Kjell Erlandsson and Erik Arstad and Lisa Squassante and Vincenzo Teneggi and Rodrigo Affonseca Bressan and John H. Krystal and Peter Joseph Ell and Lyn S. Pilowsky},
  journal={Psychopharmacology},
  year={2007},
  volume={197},
  pages={401-408}
}
Ketamine induces effects resembling both positive and negative psychotic symptoms of schizophrenia. These are thought to arise through its action as an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. We used [123I]CNS-1261 to study ketamine binding to NMDA receptors in healthy human controls in vivo and its relationship to positive and… CONTINUE READING