Relationship between intrinsic activities of agonists in normal and desensitized tissue and agonist-induced loss of beta adrenergic receptors.

@article{Pittman1984RelationshipBI,
  title={Relationship between intrinsic activities of agonists in normal and desensitized tissue and agonist-induced loss of beta adrenergic receptors.},
  author={Randall Pittman and Elwood E. Reynolds and Perry B. Molinoff},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={230 3},
  pages={
          614-8
        }
}
The intrinsic activities of 14 agonists at beta adrenergic receptors were determined in membranes prepared from control L6 muscle cells or from cells preincubated in the presence of isoproterenol for 20 min. Several drugs that were full agonists when studied with membranes from naive cells were partial agonists in membranes prepared from desensitized cells. Prolonged incubation of cells with agonists resulted in a 70 to 80% decrease in the density of beta adrenergic receptors. This effect was… CONTINUE READING

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