Relationship between internalization and cytotoxicity of ricin A-chain immunotoxins.

@article{Preijers1988RelationshipBI,
  title={Relationship between internalization and cytotoxicity of ricin A-chain immunotoxins.},
  author={Frank W. M. B. Preijers and W. J. M. Tax and Theo de Witte and A Janssen and H vd Heijden and Hubert Vidal and Johannes M. C. Wessels and Peter J. A. Capel},
  journal={British journal of haematology},
  year={1988},
  volume={70 3},
  pages={289-94}
}
Immunotoxins (ITs) appear to vary considerably in their killing efficiency towards antigen positive cells. In order to unravel the mechanisms underlying these differences, the parameters responsible for these variations were studied. The efficacy of the monoclonal antibodies (MoAbs) WT32 (CD3), OKT4 (CD4), T101 (CD5), WT1 (CD7) and WT82 (CD8) conjugated to… CONTINUE READING