Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

@article{Taylor1991RelationshipBI,
  title={Relationship between interferon‐$\gamma$, indoleamine 2,3‐dioxygenase, and tryptophan catabolism},
  author={Milton W. Taylor and Gensheng Feng},
  journal={The FASEB Journal},
  year={1991},
  volume={5},
  pages={2516 - 2522}
}
Interferons have been shown to be potential anti‐cancer agents and to inhibit tumor cell growth in culture. The in vivo mechanism of the anti‐proliferative effect may be direct or indirect through the immune system; however, in vitro a primary mechanism of cytotoxicity is through the depletion of tryptophan. In particular, interferon‐γ (IFN‐γ) induces an enzyme of tryptophan catabolism, indoleamine 2,3‐dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole… 

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