Relationship between insulin release and 65zinc efflux from rat pancreatic islets maintained in tissue culture.

@article{Formby1984RelationshipBI,
  title={Relationship between insulin release and 65zinc efflux from rat pancreatic islets maintained in tissue culture.},
  author={Bent Formby and F Schmid-Formby and Gerold M. Grodsky},
  journal={Diabetes},
  year={1984},
  volume={33 3},
  pages={
          229-34
        }
}
In short-term batch-incubation or perfusion experiments, we studied insulin release and associated 65Zn efflux from rat pancreatic islets loaded with 65Zn by 24-h tissue culture in low-glucose medium. The fractional basal insulin release and 65Zn efflux were 0.4% and 3% of total content/h/islet, respectively. Thus, basal 65Zn efflux was much greater than that to be accounted for if zinc was released proportionally with insulin release only; extragranular zinc flux was suggested. Two millimolar… CONTINUE READING
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