Relationship between in vivo skin blanching and in vitro release rate for betamethasone valerate creams.

@article{Shah1992RelationshipBI,
  title={Relationship between in vivo skin blanching and in vitro release rate for betamethasone valerate creams.},
  author={Vinod P. Shah and Jacob S. Elkins and Jerome Philip Skelly},
  journal={Journal of pharmaceutical sciences},
  year={1992},
  volume={81 1},
  pages={104-6}
}
Betamethasone valerate creams from two firms were evaluated using the skin blanching procedure. In both studies, the same cream formulation exhibited significantly higher blanching compared to the other product. An in vitro release rate was determined for these betamethasone valerate cream products using a diffusion cell system, with a cellulose acetate membrane and a 60% ethanol:water receptor medium. The release rate (flux) of betamethasone valerate was higher for the higher blanching… CONTINUE READING
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