Relationship between in vitro dissolution rates, solubilities, and LT50's in mice of some salts of benzphetamine and etryptamine

@inproceedings{Morozowich1962RelationshipBI,
  title={Relationship between in vitro dissolution rates, solubilities, and LT50's in mice of some salts of benzphetamine and etryptamine},
  author={Walter Morozowich and Thomas. Chulski and William E. Hamlin and P M Jones and Jack I. Northam and Andrejs Purmalis and John G. Wagner},
  year={1962}
}
Salt formation of benzphetamine and etryptamine as a potential means of obtaining sustained release and/or prolonged action was studied by measuring the median lethal time (LT50) in mice and its relationship to in vitro dissolution rates and solubilities. Both the LT50 and LD50 increase as the in vitro dissolution rate, determined at pH 7.2, decreases. An empirical relationship was found between the LT50 and the in vitro dissolution rate at pH 7.2. The experimental data suggest that salt… CONTINUE READING

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