Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis.

@article{Steere2011RelationshipBI,
  title={Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis.},
  author={Allen C. Steere and Elise E. Drouin and Lisa J. Glickstein},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011},
  volume={52 Suppl 3},
  pages={s259-65}
}
Antibiotic-refractory Lyme arthritis may result from Borrelia burgdorferi-induced autoimmunity in affected joints. Such patients usually have certain HLA-DRB1 molecules that bind an epitope of B. burgdorferi outer-surface protein A (OspA₁₆₃₋₁₇₅), and cellular and humoral immune responses to OspA are greater in patients with antibiotic-refractory arthritis than in those with antibiotic-responsive arthritis. Recent work in a mouse model suggests that, during B. burgdorferi infection, OspA in… CONTINUE READING

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T regulatory cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis

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