Relationship between gamma-hydroxybutyrate plasma concentrations and its electroencephalographic effects in the rat.

@article{Sassenbroeck2001RelationshipBG,
  title={Relationship between gamma-hydroxybutyrate plasma concentrations and its electroencephalographic effects in the rat.},
  author={Diederik K Van Sassenbroeck and Peter de Paepe and Frans M. Belpaire and Marie T. Rosseel and Penny Martens and Paul A.J.M Boon and Walter A. Buylaert},
  journal={The Journal of pharmacy and pharmacology},
  year={2001},
  volume={53 12},
  pages={1687-96}
}
In view of the potential interest in an objective parameter for the depth of coma in intoxications with the recreational drug gamma-hydroxybutyrate (GHB), we have studied the relationship between the plasma concentrations and the electroencephalographic (EEG) changes induced by GHB in the rat. Fifteen rats randomly received either 150 (n = 3), 200 (n = 6) or 300 mg kg(-1) (n = 6) GHB over 5 min, followed by a supramaximal dose of 450 mg kg(-1) over 5 min at the end of the experiment. Plasma… CONTINUE READING