Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.

@article{Akkiz2010RelationshipBF,
  title={Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.},
  author={Hikmet Akkiz and S{\"u}leyman Bayram and Aynur Bekar and Ersin Akg{\"o}ll{\"u} and Burhan Ozdil},
  journal={Journal of viral hepatitis},
  year={2010},
  volume={17 9},
  pages={668-74}
}
Aurora A is considered a potential cancer susceptibility gene owing to overexpression or amplification of Aurora A gene that causes centrosome dysfunction, chromosome instability, tumourigenic transformation and checkpoint abnormalities. Functional coding region polymorphism F31I in the Aurora A gene has recently been shown to be associated with several human cancers, but its association with hepatocellular carcinoma (HCC) has yet to be investigated. Genetic polymorphism of Aurora A was… CONTINUE READING

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