Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome

@article{Mihara2003RelationshipBF,
  title={Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome},
  author={K. Mihara and T. Kondo and A. Suzuki and N. Yasui-Furukori and S. Ono and A. Sano and K. Koshiro and K. Otani and S. Kaneko},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2003},
  volume={117B}
}
  • K. Mihara, T. Kondo, +6 authors S. Kaneko
  • Published 2003
  • Biology, Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Our previous study has suggested that the TaqI A polymorphism of dopamine D2 receptor gene (DRD2) is associated with the predisposition to neuroleptic malignant syndrome (NMS). However, the specificity of this polymorphism as a predictor of NMS dose not seem to be sufficient enough. Meanwhile, it has been shown that the non‐carriers of Del allele of the −141C Ins/Del polymorphism in the promoter region of DRD2 have lower dopamine D2 receptor in the brain than the carriers. In addition, dopamine… Expand
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