Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis.

@article{Varella2011RelationshipBF,
  title={Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis.},
  author={Pedro Paulo Vasconcellos Varella and Joselita Ferreira Carvalho Santiago and Henrique H. Carrete and Elisa Mieko Suemitsu Higa and Elza M{\'a}rcia Targas Yacubian and Ricardo da Silva Centeno and Lu{\'i}s Ot{\'a}vio Sales Ferreira Caboclo and Eduardo Ferreira de Castro Neto and Mauro Canzian and D{\'e}bora Amado and Esper Abr{\~a}o Cavalheiro and Maria da Graça Naffah-Mazzacoratti},
  journal={Arquivos de neuro-psiquiatria},
  year={2011},
  volume={69 1},
  pages={91-9}
}
We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal… CONTINUE READING

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[ The effect of the time of death on the reactivity of rat caudal artery regulated by NA with a simultaneous use of NOS , CG and COX inhibitors . Part I ]

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