Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines.

@article{Ando2008RelationshipBE,
  title={Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines.},
  author={Takafumi Ando and Hideyuki Ishiguro and Yoshiyuki Kuwabara and Masahiro Kimura and Akira Mitsui and Nobuyoshi Sugito and R. De Mori and Ryo Ogawa and Takeyasu Katada and Yoshitaka Fujii},
  journal={Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus},
  year={2008},
  volume={21 1},
  pages={15-20}
}
5-Fluorouracil (5-FU) is a key drug in the treatment of esophageal squamous cell carcinoma (ESCC). Gene expression of 5-FU metabolic enzymes such as thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT), has recently been investigated in order to predict the 5-FU sensitivity of several cancers. We examined the relationship between such gene expression and 5-FU sensitivity in 25 ESCC cell lines. TS, DPD, TP… CONTINUE READING