Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics.

@article{Ueda2000RelationshipBE,
  title={Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics.},
  author={Yoshihide Ueda and E. L. Gong and Lori J. Royer and Paul N Cooper and Omar L. Francone and Edward M. Rubin},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 27},
  pages={20368-73}
}
Both in vitro and in vivo studies of scavenger receptor class B type I (SR-BI) have implicated it as a likely participant in the metabolism of HDL cholesterol. To investigate the effect of SR-BI on atherogenesis, we examined two lines of SR-BI transgenic mice with high (10-fold increases) and low (2-fold increases) SR-BI expression in an inbred mouse background hemizygous for a human apolipoprotein (apo) B transgene. Unlike non-HDL cholesterol levels that minimally differed in the various… CONTINUE READING