Relationship between endothelin-1 binding site densities and constrictor activities in human and animal airway smooth muscle.

@article{Henry1990RelationshipBE,
  title={Relationship between endothelin-1 binding site densities and constrictor activities in human and animal airway smooth muscle.},
  author={Peter J. Henry and Paul J. Rigby and Glenn J Self and J. M. H. Preuss and Roy G. Goldie},
  journal={British journal of pharmacology},
  year={1990},
  volume={100 4},
  pages={786-92}
}
1. Endothelin-1 (ET-1) binding site densities and constrictor activities were compared in airway smooth muscle preparations of human, guinea-pig, rat and mouse. 2. The mean contractile response to 0.3 microM ET-1 (measured as the % maximum response to 10 microM carbachol, % Cmax +/- s.e.mean) and the mean concentration of ET-1 producing 30% Cmax (95% confidence limits) were respectively; 85.9 +/- 5.4% and 3.4 nM (2.4-5.0) for mouse trachea (n = 11), 88.8 +/- 4.7% and 18.2 nM (11.2-25.2) for rat… CONTINUE READING

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