Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).

@article{Kim2008RelationshipBD,
  title={Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).},
  author={I H Kim and Catherine L. Booth-Genthe and Suresh V Ambudkar},
  journal={Mini reviews in medicinal chemistry},
  year={2008},
  volume={8 3},
  pages={193-200}
}
P-glycoprotein (Pgp, ABCB1) is an efflux transporter for a variety of amphipathic agents that can affect the pharmacokinetics of drugs. In order to extrapolate transport and pharmacokinetic data of the drug candidates obtained from in vitro and animal models to those in humans, it is important to understand the functional differences of Pgps from various mammalian species including human, monkey, dog, rat, and mouse. Here, we review differences/similarities in the properties of Pgp from… CONTINUE READING

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