Relationship between drug effects and particle size of insulin-loaded bioadhesive microspheres.


AIM To formulate and characterize insulin-loaded adhesive microspheres (MP) and evaluate drug effects of MP with various sizes, 120, 350, and 1000 nm in diameter, in the alloxan-induced diabetic rats. METHODS Insulin-loaded MP were formulated by an ionotropic gelation procedure. Particle size distributions were determined by photon correlation… (More)


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