• DOI:10.31288/oftalmolzh201814953
• Corpus ID: 81897223

Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus

@article{Zherdiova2018RelationshipBD,
  title={Relationship between diabetic retinopathy and cerebral perfusion in type 2 diabetes mellitus},
  author={N. M. Zherdiova and N. V. Medvedovska and Boris N. Mankovsky},
  journal={Oftalmologicheskiĭ zhurnal},
  year={2018},
  volume={71},
  pages={49-53}
}

• N. Zherdiova, N. Medvedovska, B. Mankovsky
• Published 31 January 2018
• Medicine
• Oftalmologicheskiĭ zhurnal

E-mail: [e-mail] Background: Compared to patients without diabetic retinopathy (DR), those with DR demonstrate better cognitive performance. It is therefore reasonable to hypothesize that retinal microcirculatory changes might be a marker of impaired cerebral microcirculation. Purpose: To examine the association between the presence of diabetic retinopathy and cerebral perfusion in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Ninety-five T2DM patients aged 50-70 years were enrolled. They were divided into two groups, those with DR (DR group) and without DR (non-DR group). Regional cerebral blood flows (rCBF) were measured with 99mTc-HMPAO single-photon emission computed tomography (SPECT). Results: Linear regression analysis revealed negative relationships between DR and cerebral perfusion impairments in right frontal lobe (B (95% CI) = 0.58 (-0.98/-0.18); P = 0.01), left frontal (B (95% CI) = -0.55 (-0.99/-0.12); P = 0.02) lobe, right parietal lobe (B (95% CI) = -0.68 (-1.19/-0.16); P = 0.01), left parietal lobe (B (95% CI) = -0.79 (-1.31/-0.27); P = 0.00); right occipital lobe (B (95% CI) = -0.61(-1.17/-0.06); P = 0.03), left occipital lobe (B (95% CI) = -0.81 (-1.35/0.26); P = 0.00); right cerebral cortex (B (95% CI) = -0,58 (-0.98/-0.18); P = 0.01) and left cerebral cortex (B (95% CI) = -0.54 (-91/-0.17); P = 0.01). Conclusions: The findings might indicate that, in diabetic patients, damage to retinal microvessels develops somewhat in parallel with that to the brain.