Relationship between cytotoxicity and conversion of thiosangivamycin analogs to toyocamycin analogs in cell culture medium.

@article{Renau1994RelationshipBC,
  title={Relationship between cytotoxicity and conversion of thiosangivamycin analogs to toyocamycin analogs in cell culture medium.},
  author={T. Renau and J. Lee and H. Kim and C. Young and L. Wotring and L. Townsend and J. Drach},
  journal={Biochemical pharmacology},
  year={1994},
  volume={48 4},
  pages={
          801-7
        }
}
Non-nucleoside analogs of the pyrrolopyrimidine nucleosides toyocamycin, sangivamycin and thiosangivamycin have been synthesized and their cytotoxicity in mammalian cells determined. While studying the effects of 5-thioamide-substituted analogs on cell growth, we observed an interesting phenomenon in which cells recovered spontaneously from growth inhibition during extended incubations. HPLC studies demonstrated that the 5-thioamide moiety of several structurally dissimilar 7-substituted 4… Expand
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