Relationship between core histone acetylation and histone H1(0) gene activity.

  title={Relationship between core histone acetylation and histone H1(0) gene activity.},
  author={V Girardot and Thierry Rabilloud and Minoru Yoshida and Teruhiko Beppu and Johnny J. Lawrence and Saadi Khochbin},
  journal={European journal of biochemistry},
  volume={224 3},
In this study we show a striking correlation between histone H1(0) gene expression and histone acetylation. Trichostatin A, a highly specific inhibitor of histone deacetylase, efficiently induces H1(0) gene expression. Moreover, using a cell line sensitive to trichostatin A (FM3A) and a derived cell line selected for its resistance to this inhibitor (TR303), it is shown that the level of H1(0) gene expression is related to the extent of chromatin acetylation. After showing the S-phase-dependent… CONTINUE READING

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