Relationship between copper, zinc and metallothionein in hepatocellular carcinoma and its surrounding liver parenchyma.

@article{Ebara2000RelationshipBC,
  title={Relationship between copper, zinc and metallothionein in hepatocellular carcinoma and its surrounding liver parenchyma.},
  author={Masaaki Ebara and Hiroyuki Fukuda and Ryoji Hatano and Hiromitsu Saisho and Y Nagato and Kenta Suzuki and Kouichi Nakajima and Masae Yukawa and Fukuo Kondo and Akiko Nakayama and Hiromu Sakurai},
  journal={Journal of hepatology},
  year={2000},
  volume={33 3},
  pages={415-22}
}
BACKGROUND/AIM Accumulation of copper (Cu) in hepatocellular carcinoma (HCC), especially in small tumors, is greater than that in the surrounding liver parenchyma. Metallothionein (MT) is considered to be present as Cu-MT, Zn,Cu-MT or Zn-MT. The aim of this study was to determine the presence and localization of Cu-MT and Zn-MT in HCC and surrounding liver parenchyma. METHODS In 16 HCC patients, surgically resected specimens including HCC and surrounding liver parenchyma were evaluated… CONTINUE READING