Relationship between codon 249 mutation in exon 7 of p53 gene and diagnosis of hepatocellular carcinoma

INTRODUCTION Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Multiple genetic and epigenetic changes are involved in the molecular pathogenesis of HCC. Heat shock proteins have essential roles in protecting cells from the potentially lethal effects of stress. Among them, HSP70 are often overexpressed in cells of various… CONTINUE READING