Relationship between clinical signs and transmission of an infectious disease and the implications for control.

@article{Charleston2011RelationshipBC,
  title={Relationship between clinical signs and transmission of an infectious disease and the implications for control.},
  author={Bryan Charleston and Bartlomies M Bankowski and Simon Gubbins and Margo E. Chase-Topping and David Schley and Richard Howey and Paul V. Barnett and Debi Gibson and Nicholas D. Juleff and Mark E. J. Woolhouse},
  journal={Science},
  year={2011},
  volume={332 6030},
  pages={726-9}
}
Control of many infectious diseases relies on the detection of clinical cases and the isolation, removal, or treatment of cases and their contacts. The success of such "reactive" strategies is influenced by the fraction of transmission occurring before signs appear. We performed experimental studies of foot-and-mouth disease transmission in cattle and estimated this fraction at less than half the value expected from detecting virus in body fluids, the standard proxy measure of infectiousness… CONTINUE READING
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