Relationship between clinical effects, serum drug concentration and serotonin uptake inhibition in depressed patients treated with citalopram. A double-blind comparison of three dose levels.

@article{Bjerkenstedt1985RelationshipBC,
  title={Relationship between clinical effects, serum drug concentration and serotonin uptake inhibition in depressed patients treated with citalopram. A double-blind comparison of three dose levels.},
  author={Lars Bjerkenstedt and L. Flyckt and Kerstin Fredricson Over\o and Odd Lingjaerde},
  journal={European journal of clinical pharmacology},
  year={1985},
  volume={28 5},
  pages={553-7}
}
Three dose levels (5, 25, and 50 mg once daily) of the selective serotonin uptake inhibitor citalopram were compared in a four-week, double-blind trial in depressed patients. Serum levels of citalopram and desmethylcitalopram, and the inhibitory effect of serum on serotonin uptake by fresh platelets, were assessed once weekly during the trial. The serum concentrations of citalopram were highly correlated with inhibition of serotonin uptake. Less of the metabolite was found, it being detected… CONTINUE READING

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