Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.

@article{Emerson2002RelationshipBC,
  title={Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.},
  author={Lyndal R Emerson and Martin E. Nau and Rodger K Martin and Dennis E. Kyle and Maryanne T. Vahey and Dyann F Wirth},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 3},
  pages={787-96}
}
Chloroquine is one of the most effective antimalarials, but resistance to it is becoming widespread. However, we do not fully understand either the drug's mode of action or the mechanism of resistance. In an effort to expand our understanding of the mechanism of action and resistance associated with chloroquine, we used Saccharomyces cerevisiae as a model eukaryotic system. To aid in the discovery of potential drug targets we applied the transcriptional profiling method to identify genes… CONTINUE READING
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