Relationship between cardiac adrenergic image and exercise testing in heart failure.


BACKGROUND The exercise treadmill test can be used in ventricular dysfunction patients for functional capacity or predicting prognosis. The cardiac image with 123I MIBG shows cardiac sympathetic activation. OBJECTIVE To evaluate the relationship between exercise treadmill test variables and cardiac image changes in 123I MIBG. METHODS 23 patients with LVEF ≤ 45% performed scintigraphy cardiac with 123I MIBG and divided into two groups. G1: Washout rate < 27%; G2: ≥ 27%. Systolic blood pressure (SBP), heart rate (HR) and functional capacity were evaluated. It was performed Student t test or Mann-Whitney U test, Spearman coefficient and linear regression. RESULTS SBP at exercise peak (G1: 181.00 ± 28.01; G2: 153.27 ± 27.71 mmHg, p = 0.027), SBP variation [G1: 64(47.5-80.5); G2: 36(25-47) mmHg, p = 0.015], the HR at exercise peak (G1: 136.91 ± 19.66; G2: 118.45 ± 13.98 bpm, p = 0.018) and chronotropic response (G1: 70.42 ± 17.94; G2: 49.47 ± 14.89%, p = 0.006), and functional capacity [G1: 8.37(6.47-10.27); G2: 4.42(2.46-6.38) METs, p = 0.003] were smaller in G2 group. There was negative correlation between Washout rate and SBP at exercise peak (r = -0.505, p = 0.014), variation in SBP (r = -0.493, p = 0.017) and functional capacity (r = -0.646, p = 0.001). Nevertheless, SBP at exercise peak (r = -0.422, p = 0.016) and functional capacity (r = -0.804, p = 0.004) were the only variables associated with Washout rate, after linear regression. CONCLUSION In heart failure patients, the SBP at exercise peak and functional capacity were the variables associated with Washout rate.

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@article{Messias2011RelationshipBC, title={Relationship between cardiac adrenergic image and exercise testing in heart failure.}, author={Leandro Rocha Messias and Maria {\^A}ngela M de Queiroz Carreira and Sandra Marina Ribeiro de Miranda and Jader Cunha de Azevedo and Isabela Ambr{\'o}sio Gava and Ronaldo Campos Rodrigues and Elizabeth Mar{\'o}stica and Ant{\^o}nio Claudio Lucas da N{\'o}brega and Claudio Tinoco Mesquita}, journal={Arquivos brasileiros de cardiologia}, year={2011}, volume={96 5}, pages={370-5} }