Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells.

@article{Yasuo2006RelationshipBC,
  title={Relationship between calcium-activated chloride channel 1 and MUC5AC in goblet cell hyperplasia induced by interleukin-13 in human bronchial epithelial cells.},
  author={Masanori Yasuo and Keisaku Fujimoto and Tsuyoshi Tanabe and Hironobu Yaegashi and Kenji Tsushima and Keiichirou Takasuna and Takeshi Koike and Mutsuo Yamaya and Toshio Nikaido},
  journal={Respiration; international review of thoracic diseases},
  year={2006},
  volume={73 3},
  pages={347-59}
}
BACKGROUND Interleukin (IL)-13 has recently been reported as the major T-helper 2 cytokine involved in mucus overproduction and oversecretion in allergic airways. However, the relationship between human calcium-activated chloride channel-1 (hCLCA1) and MUC5AC induced by IL-13 in vitro has not been fully investigated. OBJECTIVES The present study examines whether IL-13 induces the expression of hCLCA1 in normal human bronchial epithelial (NHBE) cells. We also investigated the relationship… CONTINUE READING
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