Relationship between blood serotonergic variables, melancholic traits, and response to antidepressant treatments.

@article{Prez1998RelationshipBB,
  title={Relationship between blood serotonergic variables, melancholic traits, and response to antidepressant treatments.},
  author={V{\'i}ctor P{\'e}rez and N{\'u}ria Bel and Pau Celada and Jordi Ortiz and Enrique L Alvarez and Francesc Casa{\~n}as Artigas},
  journal={Journal of clinical psychopharmacology},
  year={1998},
  volume={18 3},
  pages={222-30}
}
The relationship between peripheral serotonergic variables, melancholic traits, and clinical improvement after antidepressant treatment was examined in 83 drug-free major depressive patients. Plasma serotonin (5-HT) concentrations was lower in untreated melancholic patients (1.00 +/- 0.11 vs. 1.84 +/- 0.28 ng/mL, p < 0.008; N = 40 and 43, respectively). A tendency was observed for plasma 5-hydroxyindoleacetic acid (p < 0.06), whereas platelet 5-HT and plasma tryptophan did not differ between… CONTINUE READING

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