Relationship between biological responsiveness to phorbol esters and receptor levels in GH4C1 rat pituitary cells.

@article{Jaken1981RelationshipBB,
  title={Relationship between biological responsiveness to phorbol esters and receptor levels in GH4C1 rat pituitary cells.},
  author={Susan Jaken and Armen H. Tashjian and Peter M. Blumberg},
  journal={Cancer research},
  year={1981},
  volume={41 12 Pt 1},
  pages={4956-60}
}
During a 24-hr incubation of GH4C1 cells with phorbol esters or thyrotropin-releasing hormone, there is a decrease in the number of phorbol esters receptors (down-modulation). The purpose of this study was to investigate whether this decrease in receptor number attenuated cellular responsiveness to subsequent challenge with phorbol esters. Accordingly, cellular sensitivity to a phorbol ester-mediated biological response, namely the decrease in binding of epidermal growth factor, was compared in… CONTINUE READING

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Studies on the mechanism by which a tumor promoter inhibits binding of epidermal growth factor to cellular receptors

  • Lee. L.-S., I. B. Weinstein
  • Carcinogenesis
  • 1980

Studies on the mechanism by which a tumor promoter inhibits binding of epidermal growth factor to cellular receptors. Carcinogenesis

  • Lee. L.-S, I. B. Weinstein
  • 1980
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