Relationship between baseline ET-1 plasma levels and outcome in patients with idiopathic pulmonary hypertension treated with bosentan.

@article{Vizza2013RelationshipBB,
  title={Relationship between baseline ET-1 plasma levels and outcome in patients with idiopathic pulmonary hypertension treated with bosentan.},
  author={Carmine Dario Vizza and Claudio Letizia and Roberto Badagliacca and Roberto Poscia and Beatrice Pezzuto and Cristina Gambardella and Alfred Nona and Silvia Papa and Serena Marcon and Massimo Mancone and Carlo Iacoboni and Valeria Riccieri and Maurzio Volterrani and Francesco Fedele},
  journal={International journal of cardiology},
  year={2013},
  volume={167 1},
  pages={220-4}
}
OBJECTIVES To address if baseline endothelin-1 (ET-1) plasma levels might predict clinical worsening (CW) in patients with idiopathic pulmonary hypertension (IPAH) treated with bosentan. METHODS Forty-four consecutive patients with IPAH (WHO classes II-III) were included in this study. After an initial assessment (clinical status, pulmonary hemodynamics, samples for adrenomedullin (ADM), ET-1 and brain natriuretic peptide (BNP) plasma levels), patients were treated with bosentan and followed… CONTINUE READING