Relationship between availability of NMDA receptor subunits and their expression at the synapse.

@article{Prybylowski2002RelationshipBA,
  title={Relationship between availability of NMDA receptor subunits and their expression at the synapse.},
  author={Kate Prybylowski and Zhanyan Fu and Gabriele Losi and Lynda M Hawkins and Jianhong Luo and Kai Ming Chang and Robert J. Wenthold and Stefano Vicini},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 20},
  pages={8902-10}
}
The effect of increasing the expression of NMDA subunits in cerebellar granule cells (CGCs) by transfection was studied to determine how the availability of various NMDA subunits controls both the total pool of functional receptors and the synaptic pool. Overexpression of either NR2A or NR2B, but not splice variants of NR1, by transfection caused a significant increase in the total number of functional NMDA receptors and in surface NR1 subunit cluster density in CGCs in primary culture. These… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

High-efficiency transformation of mammalian cells by plasmid DNA.

Molecular and cellular biology • 1987
View 4 Excerpts
Highly Influenced

NMDA receptor subunits: diversity, development and disease.

Current opinion in neurobiology • 2001
View 5 Excerpts
Highly Influenced

Subtype-dependence of NMDA receptor channel open probability.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 5 Excerpts
Highly Influenced

The glutamate receptor ion channels.

View 7 Excerpts
Highly Influenced

The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1997
View 1 Excerpt
Highly Influenced

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