Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat: could autophagy be a "brake" in paraquat-induced apoptotic death?

@article{GonzlezPolo2007RelationshipBA,
  title={Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat: could autophagy be a "brake" in paraquat-induced apoptotic death?},
  author={Rosa Ana Gonz{\'a}lez-Polo and Mireia Niso-Santano and Miguel A. Ortiz-Ortiz and Ana G{\'o}mez-Mart{\'i}n and Jose M Moran and Lourdes Garc{\'i}a-Rubio and Javier Francisco-Morcillo and Concepci{\'o}n Zaragoza and Germ{\'a}n Soler and Jos{\'e} M Fuentes},
  journal={Autophagy},
  year={2007},
  volume={3 4},
  pages={366-7}
}
Paraquat (PQ) (1, 1'-dimethyl-4, 4'-bipyridinium dichloride), a widely used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). In neurons from patients with PD display characteristics of autophagy, a degradative mechanism involved in the recycling and turnover of cytoplasmic constituents from eukaryotic cells. Low concentrations of paraquat have been recently found to induce autophagy in human neuroblastoma cells, and ultimately the… CONTINUE READING

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