Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.

  title={Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.},
  author={Ga{\"e}l Ch{\'e}telat and Victor Villemagne and Pierrick T. Bourgeat and Kerryn Elizabeth Pike and Gareth Jones and David Ames and Kathryn A. Ellis and Cassandra Szoeke and Ralph N. Martins and Graeme J. O'Keefe and Olivier Salvado and Colin L. Masters and Christopher C. Rowe},
  journal={Annals of neurology},
  volume={67 3},
OBJECTIVE Elucidating the role of aggregated beta-amyloid in relation to gray matter atrophy is crucial to the understanding of the pathological mechanisms of Alzheimer disease and for the development of therapeutic trials. The present study aims to assess this relationship. METHODS Brain magnetic resonance imaging and [(11)C]Pittsburgh compound B (PiB)-positron emission tomography scans were obtained from 94 healthy elderly subjects (49 with subjective cognitive impairment), 34 patients with… CONTINUE READING
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