Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats.

@article{Sivonova2007RelationshipBA,
  title={Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats.},
  author={M Kmetov Sivonova and Zuzana Tatarkov{\'a} and Zdeňka Ďura{\vc}kov{\'a} and Dusan Dobrota and Jan Lehotsky and Tatiana Mat{\'a}kov{\'a} and Peter Kapl{\'a}n},
  journal={Physiological research},
  year={2007},
  volume={56 6},
  pages={757-64}
}
Oxidative stress has been implicated to play a major role in aging and age-related diseases. In the present study, we investigated the effects of aging on the total antioxidant capacity, uric acid, lipid peroxidation, total sulfhydryl group content and damage to DNA in adult (6 months), old (15 months) and senescent (26 months) male Wistar rats. The antioxidant capacity, determined by phycoerythrin-based TRAP method (total peroxyl radical-trapping potential) was significantly decreased in the… CONTINUE READING

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