Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene.

@article{Feng2010RelationshipBA,
  title={Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene.},
  author={Li-juan Feng and Zhe Wan and Xiao-hong Wang and Ruo-yu Li and Wei Liu},
  journal={Chinese medical journal},
  year={2010},
  volume={123 5},
  pages={544-8}
}
BACKGROUND The cytochrome P450 lanosterol 14alpha-demethylase (Erg11p) encoded by ERG11 gene is the primary target for azole antifungals. Changes in azole affinity of this enzyme caused by amino acid substitutions have been reported as a mechanism of azole antifungal resistance. This study aimed to investigate the relationship between amino acid… CONTINUE READING