Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone.

@article{Andren2005RelationshipBA,
  title={Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone.},
  author={Lotta Andr{\'e}en and Inger Sundstr{\"o}m-Poromaa and M Bixo and Agneta Andersson and Sigrid Nyberg and Torbj{\"o}rn Carl B{\"a}ckstr{\"o}m},
  journal={Psychoneuroendocrinology},
  year={2005},
  volume={30 2},
  pages={212-24}
}
OBJECTIVE To compare severity of negative mood and physical symptoms between women with different progesterone, allopregnanolone, and pregnanolone plasma concentrations during sequential Hormone Replacement Therapy (HRT) with vaginal progesterone suppositories. DESIGN A randomized, placebo-controlled, double-blind, crossover study. METHOD Postmenopausal women (n=36) with climacteric symptoms were treated with 2mg estradiol daily during three 28-day cycles. Vaginal progesterone suppositories… CONTINUE READING
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