Relationship between TMEM16A/anoctamin 1 and LRRC8A

Abstract

TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca2+ or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels. (i) TMEM16A/ANO1 and LRRC8 are inhibited by identical compounds, (ii) the volume-regulated anion channel VRAC requires… (More)
DOI: 10.1007/s00424-016-1862-1

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@article{Benedetto2016RelationshipBT, title={Relationship between TMEM16A/anoctamin 1 and LRRC8A}, author={Roberta Di Benedetto and Lalida Sirianant and Ines Pankonien and Podchanart Wanitchakool and Jiraporn Ousingsawat and In{\^e}s Cabrita and Rainer Schreiber and Margarida D Amaral and Karl Kunzelmann}, journal={Pfl{\"{u}gers Archiv - European Journal of Physiology}, year={2016}, volume={468}, pages={1751-1763} }