Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse.

@article{Chabi2009RelationshipBS,
  title={Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse.},
  author={B{\'e}atrice Chabi and Peter J. Adhihetty and Michael F N O'Leary and Keir Joe Menzies and David A. Hood},
  journal={Journal of applied physiology},
  year={2009},
  volume={107 6},
  pages={1730-5}
}
Sirt1 is a NAD(+)-dependent histone deacetylase that interacts with the regulatory protein of mitochondrial biogenesis PGC-1alpha and is sensitive to metabolic alterations. We assessed whether a strict relationship between the expression of Sirt1, mitochondrial proteins, and PGC-1alpha existed across tissues possessing a wide range of oxidative capabilities, as well as in skeletal muscle subject to chronic use (voluntary wheel running or electrical stimulation for 7 days, 10 Hz; 3 h/day) or… CONTINUE READING
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