Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.

@article{Serra1999RelationshipBP,
  title={Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.},
  author={Massimo Serra and Daniela Maurici and Katia Scotlandi and Giuseppe Barbanti-Brodano and Maria Cristina Manara and Stefania Benini and Piero Picci and Franco Bertoni and Gaetano Bacci and Sandra Sottili and Nicola Baldini},
  journal={International journal of oncology},
  year={1999},
  volume={14 2},
  pages={301-7}
}
The transcription of MDR1 gene may be increased by mutation or loss of function of p53 gene. In this study, we investigated whether in osteosarcoma, the p53 status is correlated with overexpression of the MDR1 gene product P-glycoprotein. The relationship between P-glycoprotein expression and p53 status was analyzed by immunohistochemistry in 64 primary and 11 metastatic high-grade osteosarcomas. In the same series, we also assessed the nuclear accumulation of MDM2 protein, whose binding to p53… CONTINUE READING

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