Relationship between Glutamate Dysfunction and Symptoms and Cognitive Function in Psychosis

  title={Relationship between Glutamate Dysfunction and Symptoms and Cognitive Function in Psychosis},
  author={Kate Merritt and Philip K. McGuire and Alice Egerton},
  booktitle={Front. Psychiatry},
The glutamate hypothesis of schizophrenia, proposed over two decades ago, originated following the observation that administration of drugs that block NMDA glutamate receptors, such as ketamine, could induce schizophrenia-like symptoms. Since then, this hypothesis has been extended to describe how glutamate abnormalities may disturb brain function and underpin psychotic symptoms and cognitive impairments. The glutamatergic system is now a major focus for the development of new compounds in… CONTINUE READING
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