Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer.

@article{Hatzis2016RelationshipBC,
  title={Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer.},
  author={Christos Hatzis and W. Fraser Symmans and Y Helen Zhang and Rebekah E Gould and Stacy Moulder and Kelly K. Hunt and Maysa Abu-Khalaf and Erin W Hofstatter and Donald R Lannin and Anees B. Chagpar and Lajos Pusztai},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 1},
  pages={
          26-33
        }
}
PURPOSE Pathologic complete response (pCR) to neoadjuvant chemotherapy reflects the cytotoxic efficacy of a drug, but patient survival is influenced by many other factors. The purpose of this study was to assess the relationship between increased pCR rate and trial-level survival benefit in triple-negative breast cancer (TNBC). EXPERIMENTAL DESIGN We used bootstrap resampling from a neoadjuvant trial to simulate trials with different pCR rates. We used estimates from Adjuvant!Online to… CONTINUE READING
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