Relationship between COX-2 expression and clinicopathological features of colorectal cancers.

@article{Zhan2004RelationshipBC,
  title={Relationship between COX-2 expression and clinicopathological features of colorectal cancers.},
  author={Jun Zhan and Jian-ping Liu and Zhao-Hua Zhu and He-rui Yao and Chun-yan Chen},
  journal={Chinese medical journal},
  year={2004},
  volume={117 8},
  pages={1151-4}
}
BACKGROUND Cyclo-oxgenase 2 (COX-2) is involved in prostaglandin synthesis in central nervous system, and it also plays a role in human carcinogenesis. Our purpose of this study is to investigate the COX-2 expression in different development stages of colorectal cancer, and to discuss the relationship between the gene expression and clinicopathological features of the cancer. METHODS COX-2 expression was examined by immunohistochemical staining in 76 surgical specimens of colorectal cancer… CONTINUE READING