Relationship Between Plasma Concentrations of Lamotrigine and Its Early Therapeutic Effect of Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder

@article{Kagawa2014RelationshipBP,
  title={Relationship Between Plasma Concentrations of Lamotrigine and Its Early Therapeutic Effect of Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder},
  author={S. Kagawa and K. Mihara and A. Nakamura and K. Nemoto and T. Suzuki and G. Nagai and T. Kondo},
  journal={Therapeutic Drug Monitoring},
  year={2014},
  volume={36},
  pages={730–733}
}
Background: The relationship between plasma concentrations of lamotrigine and its therapeutic effects was prospectively studied on 34 (9 men and 25 women) inpatients with treatment-resistant depressive disorder during an 8-week treatment of lamotrigine augmentation using an open-study design. Methods: The subjects were depressed patients who had already shown insufficient response to at least 3 psychotropics, including antidepressants, mood stabilizers, and atypical antipsychotics. The… Expand
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