Relationship Between Neuroticism Personality Trait and Serotonin Transporter Binding

  title={Relationship Between Neuroticism Personality Trait and Serotonin Transporter Binding},
  author={Akihiro Takano and Ryosuke Arakawa and Mika Hayashi and Hidehiko Takahashi and Hiroshi Ito and Tetsuya Suhara},
  journal={Biological Psychiatry},

No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study

The findings indicate that NEO personality traits and 5-HT4R are not related in healthy participants and suggest that5-HT tone per se is not directly implicated in normal personality traits.

Neuroticism and serotonin 5-HT1A receptors in healthy subjects

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females

It is found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality, which suggests that contribution of thalamus and striatum serotonin transporter to the risk of affective disorders depends on sex.

Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects

It is suggested that neuropsychological and personality measurements in young healthy people are not associated with subcortical SERT or striatal DAT availabilities in the brain.

Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

The results indicate that differences in 5‐HT2AR availability are not related to variations in trait Openness in healthy individuals and that stimulation of the 5‐ HT2AR with compounds such as psilocybin may contribute to long‐term changes in traits Openness.

A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

The results of this study suggest that the expression of Neuroticism and Extraversion is related to baseline function of the opioid neurotransmitter system in the insular cortex, which may help elucidate the neural mechanisms underlying theexpression of personality traits, particularly those implicated in affective processing.

Genetic Influences on Implicit Measures of Personality

Previous research has revealed various relationships between self-reported personality traits and specific variations in genes influencing serotonergic and dopaminergic pathways. In recent studies,

Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders

Positron emission tomography has, for 30 years, been used in numerous case-control studies searching for hypothesized differences in the density of neuroreceptor or transporter proteins in



The serotonin system and spiritual experiences.

This finding in normal male subjects indicated that the serotonin system may serve as a biological basis for spiritual experiences, and the authors speculated that the several-fold variability in 5-HT(1A) receptor density may explain why people vary greatly in spiritual zeal.

Dopamine D2 Receptors in the Insular Cortex and the Personality Trait of Novelty Seeking

There is a significant association between dopamine D2 receptor binding and the human novelty seeking trait in the right insular cortex, and a significant negative correlation was observed between binding potential values and the novelty seeking scores on TCI in theright insularity.

In Vivo Serotonin 5HT2A Receptor Binding and Personality Traits in Healthy Subjects: A Positron Emission Tomography Study

These results support the concept that the variability of PET data may be explained by neurochemical differences related to the prevalence of specific personality traits, and indicate the existence of a relationship between behavioral and neurobiological factors.

Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis

While it cannot rule out an association between the 5HTT gene and anxiety-related traits, particularly for TCI/TPQ harm avoidance, the findings do indicate that the effect, if present, is small.

Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes.

The magnitude of regional 5-HTT BP can provide a vulnerability to low levels of extracellular serotonin and symptoms of extremely negativistic dysfunctional attitudes in subjects with a history of major depressive episodes.

A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety

The findings indicate that 5-HTTLPR may in fact have a small but reliable influence on personality, particularly in the manifestation of trait anxiety when measured with a neuroticism scale based on the five-factor model of personality.

Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits

  • S. SenM. BurmeisterD. Ghosh
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2004
There is a strong association between the serotonin transporter promoter variant and neuroticism as measured in the NEO personality inventory and that non‐replications are largely due to small sample size and the use of different inventories.