Relationship Between NMO-Antibody and Anti–MOG Antibody in Optic Neuritis

@article{Kezuka2012RelationshipBN,
  title={Relationship Between NMO-Antibody and Anti–MOG Antibody in Optic Neuritis},
  author={Takeshi Kezuka and Yoshihiko Usui and Naoyuki Yamakawa and Yoshimichi Matsunaga and Ryusaku Matsuda and Masayuki Masuda and Hiroya Utsumi and Keiko Tanaka and Hiroshi Goto},
  journal={Journal of Neuro-Ophthalmology},
  year={2012},
  volume={32},
  pages={107–110}
}
Background: Damage to astrocytes by anti-aquaporin-4 antibody (AQP4-Ab), also known as NMO antibody, has been implicated as the cause of neuromyelitis optica. Myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of multiple sclerosis (MS). MOG antigen is currently considered as a cause of optic neuritis (ON) associated with MS because immunization with MOG antigen derived from oligodendrocytes induces murine ON with myelitis. We investigated the relationship between… 

Clinical Profile of Anti-Myelin Oligodendrocyte Glycoprotein Antibody Seropositive Cases of Optic Neuritis

TLDR
MOG-Abs may contribute to the heterogeneous clinical picture of optic neuritis, and although visual acuity outcome is favourable, there is a tendency of residual visual field deficit and a possibility of repeated relapses.

Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis

TLDR
MOG antibodies have a strong association with BON and may be a useful clinical biomarker, and Class II evidence that MOG antibodies are associated with AQP4 antibody–negative BON is provided.

Glycine receptor and myelin oligodendrocyte glycoprotein antibodies in Turkish patients with neuromyelitis optica

Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders

TLDR
Patients with NMOSD with MOG antibodies have distinct clinical features, fewer attacks, and better recovery than patients with AQP4 antibodies or patients seronegative for both antibodies.

Myelin oligodendrocyte glycoprotein antibodies in neurological disease

TLDR
Antibodies against myelin oligodendrocyte glycoprotein (MOG-Abs) that are detectable with cell-based assays are associated with non-MS acquired demyelinating syndromes of the CNS, including the value of detection assays and evidence for antibody pathogenicity and its mechanism.

Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype

TLDR
MOG-seropositive patients show a diverse clinical phenotype with clinical features resembling both NMO and MS with an opticospinal presentation, and anti-MOG antibodies can serve as a diagnostic and maybe prognostic tool in patients with an AQP4-seronegative NMO phenotype.

MOG cell-based assay detects non-MS patients with inflammatory neurologic disease

TLDR
This study provides Class II evidence that the presence of serum IgG1- MOG-Abs in AQP4-Ab–negative patients distinguishes non-MS CNS demyelinating disorders from MS (sensitivity 24, 95% confidence interval [CI] 9%–45%; specificity 100%, 95% CI 88%–100%).

Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis

TLDR
Although not proving primary pathogenicity of anti-MOG antibodies, the present results indicate that the measurement of MOG antibodies is useful in diagnosing and treating ON.
...

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TLDR
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TLDR
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TLDR
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TLDR
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