Relationship Between Gap-Junctional Conductance and Conduction Velocity in Mammalian Myocardium

@article{Dhillon2013RelationshipBG,
  title={Relationship Between Gap-Junctional Conductance and Conduction Velocity in Mammalian Myocardium},
  author={Paramdeep S. Dhillon and Rosaire Gray and Pipin Kojodjojo and Rita I. Jabr and Rasheda A. Chowdhury and Christopher Henry Fry and Nicholas S. Peters},
  journal={Circulation: Arrhythmia and Electrophysiology},
  year={2013},
  volume={6},
  pages={1208–1214}
}
Background—Gap junction resistivity, Rj, has been proposed as a key determinant of conduction velocity (CV). However, studies in connexin-gene knockout mice demonstrated significant CV slowing only with near-complete connexin deletion, and these findings led to the concept of a significant redundancy of myocardial gap junctions. We challenged this prevailing concept and addressed the hypothesis that there is a continuous relationship between Rj and CV, each independently measured in human and… 
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