Relationship Between Changes of Active Oxygen Metabolism and Blood Flow and Formation, Progression, and Recovery of Lesions in Gastric Mucosa of Rats with a Single Treatment of Compound 48/80, a Mast Cell Degranulator

@article{Ohta2004RelationshipBC,
  title={Relationship Between Changes of Active Oxygen Metabolism and Blood Flow and Formation, Progression, and Recovery of Lesions in Gastric Mucosa of Rats with a Single Treatment of Compound 48/80, a Mast Cell Degranulator},
  author={Y. Ohta and T. Kobayashi and K. Nishida and I. Ishiguro},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={42},
  pages={1221-1232}
}
  • Y. Ohta, T. Kobayashi, +1 author I. Ishiguro
  • Published 2004
  • Biology, Medicine
  • Digestive Diseases and Sciences
  • The relationship between the changes of activeoxygen metabolism and blood flow and the formation,progression, and recovery of lesions was examined in thegastric mucosa of rats treated once with compound 48/80, a mast cell degranulator. Gastricmucosal lesions appeared 0.5 hr after compound 48/80treatment, became worst at 3 hr, and recovered fairlywell at 12 hr. Increases in gastric mucosal lipidperoxide content and xanthine oxidase andmyeloperoxidase activities and decreases in gastricmucosal… CONTINUE READING
    31 Citations
    Repeated recurrence of gastric mucosal lesions in rats after a single treatment with compound 48/80, a mast cell degranulator.
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