Relations between intracellular ions and energy metabolism: a study with monensin in synaptosomes, neurons, and C6 glioma cells.

@article{Ereciska1991RelationsBI,
  title={Relations between intracellular ions and energy metabolism: a study with monensin in synaptosomes, neurons, and C6 glioma cells.},
  author={Maria Erecińska and Fiorenzo Dagani and Dominic Nelson and Joseph Deas and Ian A. Silver},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 8},
  pages={2410-21}
}
Treatment of rat brain synaptosomes with 10 microM monensin stimulated activity of the Na/K pump, which enhanced oxygen consumption and lactate production. Glycolytic flux was also increased independently of the pump activation by a fall in [H+]i. Under such conditions, glycolysis provided 26% of ATP for the ouabain-sensitive ATPase, a value substantially greater than the 4% obtained in veratridine-treated preparations (Erecińska and Dagani, 1990). In C6 glioma cells, a glia-derived line… CONTINUE READING

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