Relation of the -514C/T polymorphism in the hepatic lipase gene to serum HDL and LDL cholesterol levels in postmenopausal women under hormone replacement therapy.

@article{YamakawaKobayashi2002RelationOT,
  title={Relation of the -514C/T polymorphism in the hepatic lipase gene to serum HDL and LDL cholesterol levels in postmenopausal women under hormone replacement therapy.},
  author={Kimiko Yamakawa-Kobayashi and Yoshiaki Somekawa and Mitsuko Fujimura and Shigeo Tomura and Tadao Arinami and Hideo Hamaguchi},
  journal={Atherosclerosis},
  year={2002},
  volume={162 1},
  pages={17-21}
}
Hepatic lipase (HL) is a lipolytic enzyme that catalyzes hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Recently, a -514C/T polymorphism in the promoter region of the HL gene was found to be associated with variations in hepatic lipase activity and serum high density lipoprotein cholesterol (HDL-C) levels. Postmenopausal hormone replacement therapy (HRT) has known favorable effects on serum lipid and lipoprotein levels. In this study, we examined the… CONTINUE READING

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