Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization.

@article{Burzotta2001RelationOT,
  title={Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization.},
  author={Francesco Burzotta and Licia Iacoviello and Augusto F Di Castelnuovo and Franco Glieca and Nicola Luciani and Roberto Zamparelli and Rocco Schiavello and Maria Benedetta Donati and Attilio Maseri and Gianfederico Possati and Felicita Andreotti},
  journal={The American journal of cardiology},
  year={2001},
  volume={88 10},
  pages={1125-8}
}
Interleukin (IL)-6 plasma levels are predictive of major cardiovascular events. The -174 G/C promoter polymorphism of the IL-6 gene affects basal levels in vivo and transcription rates in vitro, but its association with IL-6 acute phase levels among patients with coronary artery disease has not been investigated. In 111 patients with multivessel coronary artery disease undergoing elective coronary artery bypass graft surgery, we prospectively assessed genotype at position -174 and serial blood… CONTINUE READING